Vitamin A Metabolism and Adipose Tissue Biology

被引：79

作者：

Frey, Simone K.

Vogel, Silke ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

来源：

NUTRIENTS | 2011年 / 3卷 / 01期

关键词：

retinol; retinoic acid; adipose tissue; cellular retinol-binding protein; beta-carotene; adipogenesis; RETINOL-BINDING-PROTEIN; SHORT-CHAIN DEHYDROGENASES/REDUCTASES; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION; ACTIVATED RECEPTOR; BETA-CAROTENE; ACYLTRANSFERASE GENE; LIPID-METABOLISM; SERUM RETINOL; PPAR-GAMMA;

D O I：

10.3390/nu3010027

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.

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收藏

页码：27 / 39

页数：13

相关论文

共 69 条

[1] Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children [J].

Aeberli, Isabelle ;

Biebinger, Ralf ;

Lehmann, Roger ;

l'Allemand, Dagmar ;

Spinas, Giatgen A. ;

Zimmermann, Michael B. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (11) :4359-4365

[2] Gene expression regulation by retinoic acid [J].

Balmer, JE ;

Blomhoff, R .

JOURNAL OF LIPID RESEARCH, 2002, 43 (11) :1773-1808

[3] Repression of Cellular Retinoic Acid-binding Protein II during Adipocyte Differentiation [J].

Berry, Daniel C. ;

Soltanian, Hooman ;

Noy, Noa .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (20) :15324-15332

[4] All-trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor β/δ and Retinoic Acid Receptor [J].

Berry, Daniel C. ;

Noy, Noa .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (12) :3286-3296

[5] Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage [J].

Blaner, William S. ;

O'Byrne, Sheila M. ;

Wongsiriroj, Nuttaporn ;

Kluwe, Johannes ;

D'Ambrosio, Diana M. ;

Jiang, Hongfeng ;

Schwabe, Robert F. ;

Hillman, Elizabeth M. C. ;

Piantedosi, Roseann ;

Libien, Jenny .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (06) :467-473

[6]

Blaner William S., 1994, P229

[7] Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects [J].

Broch, Montserrat ;

Vendrell, Joan ;

Ricart, Wifredo ;

Richart, Cristobal ;

Fernandez-Real, Jose-Manuel .

DIABETES CARE, 2007, 30 (07) :1802-1806

[8] CRBP-III:lacZ expression pattern reveals a novel heterogeneity of vascular endothelial cells [J].

Caprioli, A ;

Zhu, HX ;

Sato, TN .

GENESIS, 2004, 40 (03) :139-145

[9] PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-GAMMA - ADIPOSE-PREDOMINANT EXPRESSION AND INDUCTION EARLY IN ADIPOCYTE DIFFERENTIATION [J].

CHAWLA, A ;

SCHWARZ, EJ ;

DIMACULANGAN, DD ;

LAZAR, MA .

ENDOCRINOLOGY, 1994, 135 (02) :798-800

[10] Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid [J].

Duester, G ;

Mic, FA ;

Molotkov, A .

CHEMICO-BIOLOGICAL INTERACTIONS, 2003, 143 :201-210

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