Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

被引：139

作者：

Rijkers, DTS ^{[1
]}

van Esse, GW ^{[1
]}

Merkx, R ^{[1
]}

Brouwer, AJ ^{[1
]}

Jacobs, HJF ^{[1
]}

Pieters, RJ ^{[1
]}

Liskamp, RMJ ^{[1
]}

机构：

[1] Univ Utrecht, Fac Pharmaceut Sci, Dept Med Chem, Utrecht Inst Pharmaceut Sci, NL-3508 TB Utrecht, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 36期

关键词：

D O I：

10.1039/b507975f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.

引用

页码：4581 / 4583

页数：3

共 41 条

[1] Alvarez SG, 1997, SYNTHESIS-STUTTGART, P413
[2] André S, 2001, CHEMBIOCHEM, V2, P822, DOI 10.1002/1439-7633(20011105)2:11<822::AID-CBIC822>3.0.CO
[3] 2-W
[4] A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction
Appukkuttan, P
Dehaen, W
Fokin, VV
Van der Eycken, E
[J]. ORGANIC LETTERS, 2004, 6 (23) : 4223 - 4225
[5] Synthesis and cholera toxin binding properties of multivalent GM1 mimics
Arosio, D
Vrasidas, I
Valentini, P
Liskamp, RMJ
Pieters, RJ
Bernardi, A
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (14) : 2113 - 2124
[6] Adhesion inhibition of F1C-fimbriated Escherichia coli and Pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands
Autar, R
Khan, AS
Schad, M
Hacker, J
Liskamp, RMJ
Pieters, RJ
[J]. CHEMBIOCHEM, 2003, 4 (12) : 1317 - 1325
[7] Azide-alkyne coupling:: A powerful reaction for bioconjugate chemistry
Breinbauer, R
Köhn, M
[J]. CHEMBIOCHEM, 2003, 4 (11) : 1147 - 1149
[8] Synthesis of novel dendrimeric systems containing NLO ligands
Brouwer, AJ
Liskamp, RMJ
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (03) : 487 - 495
[9] Brouwer AJ, 2001, EUR J ORG CHEM, V2001, P1903
[10] Peptide and amide bond-containing dendrimers
Crespo, L
Sanclimens, G
Pons, M
Giralt, E
Royo, M
Albericio, F
[J]. CHEMICAL REVIEWS, 2005, 105 (05) : 1663 - 1681

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