Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma

被引:77
作者
Brunelli, Matteo [1 ]
Eccher, Albino [1 ]
Gobbo, Stefano [1 ]
Ficarra, Vincenzo [2 ]
Novara, Giacomo [2 ]
Cossu-Rocca, Paolo [3 ]
Bonetti, Franco [1 ]
Menestrina, Fabio [1 ]
Cheng, Liang
Eble, John N. [4 ]
Martignoni, Guido [1 ]
机构
[1] Univ Verona, Dept Pathol, I-37100 Verona, Italy
[2] Univ Padua, Urol Clin, Dept Oncol & Surg Sci, Padua, Italy
[3] Univ Sassari, Dept Pathol, I-07100 Sassari, Italy
[4] Indiana Univ, Dept Pathol & Lab Med, Indianapolis, IN 46204 USA
关键词
clear cell renal cell carcinoma; interphase cytogenetics; fluorescence in situ hybridization; chromosome 9p loss; prognosis; SSIGN score;
D O I
10.1038/modpathol.3800967
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Loss of chromosome 9p has been implicated in the progression of renal cell carcinoma. We evaluated the clinical utility of fluorescence in situ hybridization analysis of loss of chromosome 9p in 73 patients with clear cell renal cell carcinomas with varied stage, size, grade, necrosis (SSIGN) scores. Loss of chromosome 9p was observed in 13 tumors (18%). The 5-year cancer-specific survival of patients without loss of chromosome 9p was 88% and was 43% in those with loss of chromosome 9p (P < 0.001). Local extension of the primary tumor according to the 2002 TNM staging system, lymph node involvement, the presence of distant metastases, and the SSIGN score were the other variables that predicted cancer-specific survival in univariate analysis. Loss of chromosome 9p was an independent prognostic factor in multivariate analysis. Our data indicate that the detection of chromosome 9p loss by fluorescence in situ hybridization analysis of clear cell renal cell carcinoma adds prognostic information beyond the pathological factors included in the current predictive models for renal cell carcinoma, such as SSIGN score.
引用
收藏
页码:1 / 6
页数:6
相关论文
共 29 条
[1]   Evaluation of the clonal relationship between primary and metastatic renal cell carcinoma by comparative genomic hybridization [J].
Bissig, H ;
Richter, J ;
Desper, R ;
Meier, V ;
Schraml, P ;
Schäffer, AA ;
Sauter, G ;
Mihatsch, MJ ;
Moch, H .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (01) :267-274
[2]   Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma [J].
Brunelli, M ;
Eble, JN ;
Zhang, SB ;
Martignoni, G ;
Delahunt, B ;
Cheng, L .
MODERN PATHOLOGY, 2005, 18 (02) :161-169
[3]   Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma [J].
Brunelli, M ;
Eble, JN ;
Zhang, SB ;
Martignoni, G ;
Cheng, L .
MODERN PATHOLOGY, 2003, 16 (10) :1060-1063
[4]  
Bugert P, 1996, AM J PATHOL, V149, P2081
[5]  
CAIRNS P, 1995, CANCER RES, V55, P224
[6]   Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma [J].
Cossu-Rocca, P ;
Eble, JN ;
Delahunt, B ;
Zhang, SB ;
Martignoni, G ;
Brunelli, M ;
Cheng, L .
MODERN PATHOLOGY, 2006, 19 (04) :488-493
[7]   Acquired cystic disease-associated renal tumors:: an immunohistochemical and fluorescence in situ hybridization study [J].
Cossu-Rocca, Paolo ;
Eble, John N. ;
Zhang, Shaobo ;
Martignoni, Guido ;
Brunelli, Matteo ;
Cheng, Liang .
MODERN PATHOLOGY, 2006, 19 (06) :780-787
[8]   External validation of the Mayo Clinic stage, size, grade and necrosis (SSIGN) score to predict cancer specific survival using a European series of conventional renal cell carcinoma [J].
Ficarra, V ;
Martignoni, G ;
Lohse, C ;
Novara, G ;
Pea, M ;
Cavalleri, S ;
Artibani, W .
JOURNAL OF UROLOGY, 2006, 175 (04) :1235-1239
[9]   Original and reviewed nuclear grading according to the Fuhrman system - A multivariate analysis of 388 patients with conventional renal cell carcinoma [J].
Ficarra, V ;
Martignoni, G ;
Maffei, N ;
Brunelli, M ;
Novara, G ;
Zanolla, L ;
Pea, M ;
Artibani, W .
CANCER, 2005, 103 (01) :68-75
[10]   An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: The SSIGN score [J].
Frank, I ;
Blute, ML ;
Cheville, JC ;
Lohse, CM ;
Weaver, AL ;
Zincke, H .
JOURNAL OF UROLOGY, 2002, 168 (06) :2395-2400