3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide

被引：30

作者：

Allsop, D

Gibson, G

Martin, IK

Moore, S

Turnbull, S

Twyman, LJ

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Univ Lancaster, Dept Biol Sci, Lancaster LA1 4YQ, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0960-894X(00)00645-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cmc and IC50 values of the beta -amyloid (A beta) aggregation inhibitors, 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)- phenyl]-benzofuran 1, and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit beta -amyloid-peptide aggregation. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：255 / 257

页数：3

共 13 条

[1]

ALLSOP D, 2000, ALZHEIMERS DIS METHO, P1

[2] EFFECTS OF AMPHIPHILE TOPOLOGY ON AGGREGATION PROPERTIES - DISTINCTIVE BEHAVIOR OF CONTRAFACIAL AMPHIPHILES [J].