Huperzine a from Huperzia species -: an ethnopharmacolgical review

被引：260

作者：

Ma, Xiaoqiang

Tan, Changheng

Zhu, Dayuan

Gang, David R.

Xiao, Peigen ^{[1
]}

机构：

[1] Peking Union Med Coll, Inst Med Plant Dev, Beijing 100094, Peoples R China

[2] Chinese Acad Sci, Beijing 100094, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[4] Univ Arizona, Dept Plant Sci, Tucson, AZ 85721 USA

[5] Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 113卷 / 01期

基金：

中国国家自然科学基金;

关键词：

huperzine A; ZT-1; Alzheimer's disease; Huperzia serrata; huperziaceae; drug discovery; bioactivities; clinical trials; traditional chinese medicine;

D O I：

10.1016/j.jep.2007.05.030

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented. (c) 2007 Elsevier Ireland Ltd. Ail rights reserved.

引用

页码：15 / 34

页数：20

共 243 条

[61] Nankakurine A, a novel C16N2-type alkaloid from Lycopodium hamiltonii [J].