Synthesis of substituted quinolines by iron-catalyzed coupling reactions between chloroenynes and Grignard reagents

被引：36

作者：

Seck, M

Franck, X

Hocquemiller, R

Figadère, B

Peyrat, JF

Provot, O

Brion, JD

Alami, M

机构：

[1] Univ Paris Sud, Lab Pharmacognosie, Fac Pharm, F-92296 Chatenay Malabry, France

[2] Univ Paris Sud, Fac Pharm, BioCIS CNRS,UMR 8076, Chim Therapeut Lab, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期

关键词：

Grignard reagents; iron; quinolines; anti-leishmania; enynes; vinyl chlorides;

D O I：

10.1016/j.tetlet.2004.01.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This letter reports the preparation of quinolines, substituted at the 2- or 3-position by a 4-substituted but-3-en-1-yne group, by the environmentally friendly iron (III)-catalyzed coupling reaction of Grignard reagents with 1-chloro-4-(2-quinolyl)but-1-en-3-yne. The extension and the scope of this non-toxic and chemoselective procedure to various functionalized unsaturated vinyl chlorides are described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1881 / 1884

页数：4

共 26 条

[21] Versatile palladium(II)-catalyzed Negishi coupling reactions with functionalized conjugated alkenyl chlorides [J].