Imaging genetics of mood disorders

被引：68

作者：

Scharinger, Christian ^{[1
]}

Rabl, Ulrich ^{[1
]}

Sitte, Harald H. ^{[2
]}

Pezawas, Lukas ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Psychiat & Psychotherapy, Div Biol Psychiat, A-1090 Vienna, Austria

[2] Med Univ Vienna, Inst Pharmacol, Ctr Physiol & Pharmacol, A-1090 Vienna, Austria

来源：

NEUROIMAGE | 2010年 / 53卷 / 03期

基金：

奥地利科学基金会;

关键词：

Imaging genetics; Mood disorders; Major depressive disorder; Emotion; Amygdala; Anterior cingulate cortex; Ventromedial prefrontal cortex; Orbitofrontal cortex; Hippocampus; Functional connectivity; Genetics; Phenotype-genotype; SEROTONIN TRANSPORTER GENE; BDNF VAL66MET POLYMORPHISM; REDUCED HIPPOCAMPAL VOLUMES; GENOME-WIDE ASSOCIATION; METHYLTRANSFERASE VAL(158)MET GENOTYPE; SUBGENUAL PREFRONTAL CORTEX; MAJOR DEPRESSIVE DISORDER; ANTERIOR CINGULATE CORTEX; NEUROTROPHIC FACTOR GENE; MORAL VALENCE DECISION;

D O I：

10.1016/j.neuroimage.2010.02.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mood disorders are highly heritable and have been linked to brain regions of emotion processing. Over the past few years, an enormous amount of imaging genetics studies has demonstrated the impact of risk genes on brain regions and systems of emotion processing in vivo in healthy subjects as well as in mood disorder patients. While sufficient evidence already exists for several monaminergic genes as well as for a few non-monoaminergic genes, such as brain-derived neurotrophic factor (BDNF) in healthy subjects, many others only have been investigated in single studies so far. Apart from these studies, the present review also covers imaging genetics studies applying more complex genetic disease models of mood disorders, such as epistasis and gene-environment interactions, and their impact on brain systems of emotion processing. This review attempts to provide a comprehensive overview of the rapidly growing field of imaging genetics studies in mood disorder research. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：810 / 821

页数：12

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