No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression

被引：32

作者：

Jessen, Frank ^{[1
]}

Schuhmacher, Anna ^{[1
]}

von Widdern, Ole ^{[1
]}

Guttenthaler, Vera ^{[1
]}

Hofels, Susanne ^{[1
]}

Suliman, Husam ^{[1
]}

Scheef, Lukas ^{[2
]}

Block, Wolfgang ^{[2
]}

Urbach, Horst ^{[2
]}

Maier, Wolfgang ^{[1
]}

Zobel, Astrid ^{[1
]}

机构：

[1] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

[2] Univ Bonn, Dept Radiol, D-53105 Bonn, Germany

来源：

PSYCHIATRIC GENETICS | 2009年 / 19卷 / 02期

关键词：

brain-derived neurotrophic factor; hippocampus; major depression; GENE POLYMORPHISM; HUMAN-MEMORY; BDNF; SCHIZOPHRENIA; MORPHOLOGY; VARIANTS; DISORDER;

D O I：

10.1097/YPG.0b013e32832080ce

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recently, an association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in patients with major depression has been reported. Here,,Ne aimed at replicating this finding in an independent German sample. We included 79 patients with unipolar major depressive episodes and 84 healthy comparison participants. The brain-derived neurotrophic factor Val66Met polymorphism was determined in all participants. The volume of the hippocampus was manually traced on high-resolution magnetic resonance images. The hippocampal volumes of patients were significantly smaller than those of the comparison participants, confirming previous reports. There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants. Psychiatr Genet 19:99-101 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

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收藏

页码：99 / 101

页数：3

相关论文

共 18 条

[1] BDNF gene variants and brain morphology in schizophrenia [J].

Agartz, I ;

Sedvall, GC ;

Terenius, L ;

Kulle, B ;

Frigessi, A ;

Hall, H ;

Jönsson, EG .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (05) :513-523

[2] Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression [J].

Anttila, S. ;

Huuhka, K. ;

Huuhka, M. ;

Rontu, R. ;

Hurme, M. ;

Leinonen, E. ;

Lehtima, T. .

JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (08) :1065-1068

[3] BDNF val66 met allele is associated with reduced hippocampal volume in healthy subjects [J].

Bueller, JA ;

Aftab, M ;

Sen, S ;

Gomez-Hassan, D ;

Burmeister, M ;

Zubieta, JK .

BIOLOGICAL PSYCHIATRY, 2006, 59 (09) :812-815

[4] Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder [J].

Choi, Myoung-Jin ;

Kang, Rhee-Hun ;

Lim, Se-Won ;

Oh, Kang-Seob ;

Lee, Min-Soo .

BRAIN RESEARCH, 2006, 1118 :176-182

[5] A neurotrophic model for stress-related mood disorders [J].

Duman, Ronald S. ;

Monteggia, Lisa M. .

BIOLOGICAL PSYCHIATRY, 2006, 59 (12) :1116-1127

[6] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].

Egan, MF ;

Kojima, M ;

Callicott, JH ;

Goldberg, TE ;

Kolachana, BS ;

Bertolino, A ;

Zaitsev, E ;

Gold, B ;

Goldman, D ;

Dean, M ;

Lu, B ;

Weinberger, DR .

CELL, 2003, 112 (02) :257-269

[7] Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression [J].

Frodl, Thomas ;

Schuele, Cornelius ;

Schmitt, Gisela ;

Born, Christine ;

Baghai, Thomas ;

Zill, Peter ;

Bottlender, Ronald ;

Rupprecht, Rainer ;

Bondy, Brigitta ;

Reiser, Maximilian ;

Moeller, Hans-Juergen ;

Meisenzahl, Eva M. .

ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (04) :410-416

[8] Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance [J].

Hariri, AR ;

Goldberg, TE ;

Mattay, VS ;

Kolachana, BS ;

Callicott, JH ;

Egan, MF ;

Weinberger, DR .

JOURNAL OF NEUROSCIENCE, 2003, 23 (17) :6690-6694

[9] Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers [J].

Ho, Beng-Choon ;

Milev, Peter ;

O'Leary, Daniel S. ;

Librant, Amy ;

Andreasen, Nancy C. ;

Wassink, Thomas H. .

ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (07) :731-740

[10] The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression [J].

Hwang, Jen-Ping ;

Tsai, Shih-Jen ;

Hong, Chen-Jee ;

Yang, Chen-Hong ;

Lirng, Jiing-Feng ;

Yang, Ya-Min .

NEUROBIOLOGY OF AGING, 2006, 27 (12) :1834-1837