Current challenges in non-invasive insulin delivery systems: A comparative review

被引：326

作者：

Khafagy, El-Sayed ^{[1
]}

Morishita, Mariko ^{[1
]}

Onuki, Yoshinori ^{[1
]}

Takayama, Kozo ^{[1
]}

机构：

[1] Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Ebara 2-4-41, Tokyo 1428501, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 15期

关键词：

non-invasive delivery system; modern insulin delivery; administration routes; marketed products; formulation technologies; future patents; DIABETES MANAGEMENT-SYSTEM; LOW-FREQUENCY SONOPHORESIS; IN-VITRO EVALUATION; COMPLEXATION POLYMER HYDROGELS; RESPIRABLE PLGA MICROSPHERES; LECITHIN-BASED MICROEMULSION; CHITOSAN BASED FORMULATIONS; INTRA-SUBJECT VARIABILITY; LARGE POROUS PARTICLES; GROWTH-FACTOR-I;

D O I：

10.1016/j.addr.2007.08.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The quest to eliminate the needle from insulin delivery and to replace it with non- or less-invasive alternative routes has driven rigorous pharmaceutical research to replace the injectable forms of insulin. Recently, various approaches have been studied involving many strategies using various technologies that have shown success in delivering insulin, which are designed to overcome the inherent barriers for insulin uptake across the gastrointestinal tract, mucosal membranes and skin. This review examines some of the many attempts made to develop alternative, more convenient routes for insulin delivery to avoid existing long-term dependence on multiple subcutaneous injections and to improve the pharmacodynamic properties of insulin. In addition, this article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modem insulin delivery for the effective treatment of diabetes. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：1521 / 1546

页数：26

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