Evaluation of two rapid immunochromatography tests for the detection of Clostridium difficile toxins

被引：11

作者：

Samra, Zmira ^{[2
,3
]}

Luzon, Avia ^{[2
,3
]}

Bishara, Jihad ^{[1
,3
]}

机构：

[1] Beilinson Med Ctr, Rabin Med Ctr, Infect Dis Unit, IL-49100 Petah Tiqwa, Israel

[2] Beilinson Med Ctr, Rabin Med Ctr, Dept Clin Microbiol, IL-49100 Petah Tiqwa, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 07期

关键词：

Clostridiumdifficile; toxins; rapid; detection;

D O I：

10.1007/s10620-007-0072-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of the study was to evaluate the performance of two rapid immunochromatography tests, the Tox A/B Quick Chek((R)) (TechLab) and the ImmunoCard Toxins A&B test (Meridian), in addition to the older Tox A/B ELISA, against PCR detection of the tcdB gene. Two hundred patient-unique stool specimens were tested. In comparison to the polymerase chain reaction results, the sensitivity and specificity of the two rapid tests were 94.7% and 97.2%, respectively; corresponding values for the ELISA were 93.6% and 94.3%. Findings on the rapid tests showed a 96% correlation with polymerase chain reaction assay and a 94% correlation with ELISA. Considering the importance of early and appropriate diagnosis of Clostridium difficile-associated diarrhea, rapid immunochromatography tests may be of great benefit to practitioners.

引用

页码：1876 / 1879

页数：4

共 18 条

[1]

al-Barrak A, 1999, Can Commun Dis Rep, V25, P65

[2] Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea [J].