Regulating antigen-receptor gene assembly

被引：119

作者：

Schlissel, MS ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1225

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genes encoding antigen receptors are unique because of their high diversity and their assembly in developing lymphocytes from gene segments through a series of site-specific DNA recombination reactions known as V(D)J rearrangement. This review focuses on our understanding of how recombination of immunoglobulin and T-cell receptor gene segments is tightly regulated despite being catalysed by a common lymphoid recombinase, which recognizes a widely distributed conserved recombination signal sequence. Probable mechanisms involve precise expression of the lymphoid-restricted recombination-activating genes RAG1 and RAG2, and developmentally regulated epigenetic alterations in template accessibility, which are targeted by transcriptional regulatory elements and involve chromatin-modifying enzymes.

引用

页码：890 / 899

页数：10

共 96 条

[1] Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system [J].

Agrawal, A ;

Eastman, QM ;

Schatz, DG .

NATURE, 1998, 394 (6695) :744-751

[2] E2A PROTEINS ARE REQUIRED FOR PROPER B-CELL DEVELOPMENT AND INITIATION OF IMMUNOGLOBULIN GENE REARRANGEMENTS [J].

BAIN, G ;

MAANDAG, ECR ;

IZON, DJ ;

AMSEN, D ;

KRUISBEEK, AM ;

WEINTRAUB, BC ;

KROP, I ;

SCHLISSEL, MS ;

FEENEY, AJ ;

VANROON, M ;

VANDERVALK, M ;

TERIELE, HPJ ;

BERNS, A ;

MURRE, C .

CELL, 1994, 79 (05) :885-892

[3] Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule [J].

Bassing, CH ;

Alt, FW ;

Hughes, MM ;

D'Auteuil, M ;

Wehrly, TD ;

Woodman, BB ;

Gärtner, F ;

White, JM ;

Davidson, L ;

Sleckman, BP .

NATURE, 2000, 405 (6786) :583-586

[4] ENGAGEMENT OF THE T-CELL RECEPTOR DURING POSITIVE SELECTION IN THE THYMUS DOWN-REGULATES RAG-1 EXPRESSION [J].

BRANDLE, D ;

MULLER, C ;

RULICKE, T ;

HENGARTNER, H ;

PIRCHER, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9529-9533

[5]

Brown ST, 1997, J IMMUNOL, V158, P5071

[6] Stepwise activation of the immunoglobulin μ heavy chain gene locus [J].

Chowdhury, D ;

Sen, R .

EMBO JOURNAL, 2001, 20 (22) :6394-6403

[7] ABERRANT REARRANGEMENTS CONTRIBUTE SIGNIFICANTLY TO THE ALLELIC EXCLUSION OF IMMUNOGLOBULIN GENE-EXPRESSION [J].

COLECLOUGH, C ;

PERRY, RP ;

KARJALAINEN, K ;

WEIGERT, M .

NATURE, 1981, 290 (5805) :372-378

[8] Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling [J].

Cowell, LG ;

Davila, M ;

Yang, KY ;

Kepler, TB ;

Kelsoe, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :207-220

[9] The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells [J].

Dinkel, A ;

Warnatz, K ;

Ledermann, B ;

Rolink, A ;

Zipfel, PF ;

Bürki, K ;

Eibel, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2215-2224

[10] Factors that influence formation of B cell repertoire [J].

Feeney, AJ .

IMMUNOLOGIC RESEARCH, 2000, 21 (2-3) :195-202

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