Functions of Nogo proteins and their receptors in the nervous system

被引：324

作者：

Schwab, Martin E. ^{[1
,2
]}

机构：

[1] Univ Zurich, CH-8057 Zurich, Switzerland

[2] ETH, CH-8057 Zurich, Switzerland

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

SPINAL-CORD-INJURY; MYELIN-ASSOCIATED GLYCOPROTEIN; CNS AXON REGENERATION; CHONDROITIN SULFATE PROTEOGLYCANS; AMYOTROPHIC-LATERAL-SCLEROSIS; TUBULAR ENDOPLASMIC-RETICULUM; NEURITE OUTGROWTH INHIBITOR; MESSENGER-RNA; A EXPRESSION; ADULT CNS;

D O I：

10.1038/nrn2936

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and their receptors - in precursor migration, neurite growth and branching in the developing nervous system - as well as a growth-restricting function during CNS maturation. The function of Nogo in the adult CNS is now understood to be that of a negative regulator of neuronal growth, leading to stabilization of the CNS wiring at the expense of extensive plastic rearrangements and regeneration after injury. In addition, Nogo proteins interact with various intracellular components and may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival.

引用

页码：799 / 811

页数：13

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