The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

被引：643

作者：

Spits, Hergen ^{[1
]}

Di Santo, James P. ^{[2
,3
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 AZ Amsterdam, Netherlands

[2] Inst Pasteur, Innate Immun Unit, Paris, France

[3] Inst Natl Sante & Rech Med, U668, Paris, France

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 01期

关键词：

NATURAL-KILLER-CELL; ROR-GAMMA-T; INDUCER CELLS; NK CELLS; TRANS-PRESENTATION; INTERFERON-GAMMA; INTERLEUKIN; 22; DIFFERENTIATION; CYTOKINE; EXPRESSION;

D O I：

10.1038/ni.1962

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research has identified what can be considered a family of innate lymphoid cells (ILCs) that includes not only natural killer (NK) cells and lymphoid tissue-inducer (LTi) cells but also cells that produce interleukin 5 (IL-5), IL-13, IL-17 and/or IL-22. These ILC subsets are developmentally related, requiring expression of the transcriptional repressor Id2 and cytokine signals through the common gamma-chain of the IL-2 receptor. The functional differentiation of ILC subsets is orchestrated by distinct transcription factors. Analogous to helper T cell subsets, these evolutionarily conserved yet distinct ILCs seem to have important roles in protective immunity, and their dysregulation can promote immune pathology.

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页码：21 / 27

页数：7

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