Ethyl (R)-3-hydroxy-4-phenylthiobutyrate: Synthesis by the bakers' yeast reduction and use as a precursor of enantiomerically pure beta-lactam

被引：11

作者：

Hayakawa, R ^{[1
]}

Shimizu, M ^{[1
]}

Fujisawa, T ^{[1
]}

机构：

[1] MIE UNIV,DEPT CHEM MAT,TSU,MIE 514,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 42期

关键词：

D O I：

10.1016/0040-4039(96)01693-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bakers' yeast reduction of ethyl 3-oxo-4-phenylthiobutanoate gave ethyl (R)-3-hydroxy-4-phenylthiobutanoate with >99%ee. The resultant enantiomerically pure alcohol was easily transformed into beta-lactam without loss of its enatiomeric purity via the oxamate derivative. Copyright (C) 1996 Elsevier Science Ltd

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页码：7533 / 7536

页数：4

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