Notch signaling: direct or what?

被引：94

作者：

Weinmaster, G ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(98)80115-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechanism(s) by which Notch signaling produces so many outcomes remains unclear.

引用

页码：436 / 442

页数：7

共 66 条

[1]

Appel B, 1998, DEVELOPMENT, V125, P371

[2] FUNCTIONAL-ANALYSIS OF THE TAN-1 GENE, A HUMAN HOMOLOG OF DROSOPHILA NOTCH [J].

ASTER, J ;

PEAR, W ;

HASSERJIAN, R ;

ERBA, H ;

DAVI, F ;

LUO, B ;

SCOTT, M ;

BALTIMORE, D ;

SKLAR, J .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1994, 59 :125-136

[3] Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines [J].

Bigas, A ;

Martin, DIK ;

Milner, LA .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (04) :2324-2333

[4] Limb development: Marginal fringe benefits [J].

Blair, SS .

CURRENT BIOLOGY, 1997, 7 (11) :R686-R690

[5] Intracellular cleavage of notch leads to a heterodimeric receptor on the plasma membrane [J].

Blaumueller, CM ;

Qi, HL ;

Zagouras, P ;

ArtavanisTsakonas, S .

CELL, 1997, 90 (02) :281-291

[6] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [J].

Brown, MS ;

Goldstein, JL .

CELL, 1997, 89 (03) :331-340

[7]

Christensen S, 1996, DEVELOPMENT, V122, P1373

[8] Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila [J].

Cohen, B ;

Bashirullah, A ;

Dagnino, L ;

Campbell, C ;

Fisher, WW ;

Leow, CC ;

Whiting, E ;

Ryan, D ;

Zinyk, D ;

Boulianne, G ;

Hui, CC ;

Gallie, B ;

Phillips, RA ;

Lipshitz, HD ;

Egan, SE .

NATURE GENETICS, 1997, 16 (03) :283-288

[9]

CONLON RA, 1995, DEVELOPMENT, V121, P1533

[10]

CRITTENDEN SL, 1994, DEVELOPMENT, V120, P2901

← 1 2 3 4 5 6 7 →