Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β-amino triazoles

被引：45

作者：

Baig, R. B. Nasir ^{[1
]}

Varma, Rajender S. ^{[1
]}

机构：

[1] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 47期

关键词：

CLICK CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; MEDICINAL CHEMISTRY; FACILE ENTRY; SOLID-PHASE; MICROWAVE; SULFAMIDATE; AZIDES; HETEROCYCLES; REACTIVITY;

D O I：

10.1039/c2cc32392c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of triazole based unnatural amino acids and beta-amino triazoles has been described via a stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with a triazole side chain.

引用

页码：5853 / 5855

页数：3

共 56 条

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