8-amino guanine accelerates tetramolecular G-quadruplex formation

被引：29

作者：

Gros, Julien ^{[1
]}

Avino, Anna ^{[2
]}

de la Osa, Jaime Lopez ^{[3
]}

Gonzalez, Carlos ^{[3
]}

Lacroix, Laurent ^{[1
]}

Perez, Alberto ^{[4
,5
]}

Orozco, Modesto ^{[4
,5
,6
]}

Eritja, Ramon ^{[2
]}

Mergny, Jean-Louis ^{[1
]}

机构：

[1] Museum Natl Hist Nat, INSERM, USM 503,U565, CRNS UMR 5153, F-75231 Paris 05, France

[2] CSIC, CIBER BBN, IRB Barcelona, E-08028 Barcelona, Spain

[3] CSIC, Inst Quim Fis Rocasolano, E-28006 Madrid, Spain

[4] Inst Recerca Biomed, Joint IRB BSC Program Computat Biol, Barcelona 08028, Spain

[5] Barcelona Supercomp Ctr, Barcelona 08034, Spain

[6] Univ Barcelona, Fac Biol, Dept Bioquim, E-08028 Barcelona, Spain

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 25期

关键词：

D O I：

10.1039/b801221k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate here that 8-amino guanine (R) strongly accelerates quadruplex formation, which makes this nucleobase the most attractive replacement for guanine in the context of tetramolecular parallel quadruplexes.

引用

页码：2926 / 2928

页数：3

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