Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors

被引：123

作者：

Boeuf, Stephane ^{[1
]}

Richter, Wiltrud ^{[1
]}

机构：

[1] Orthopaed Univ Hosp Heidelberg, Res Ctr Expt Orthopaed, D-69118 Heidelberg, Germany

来源：

STEM CELL RESEARCH & THERAPY | 2010年 / 1卷

关键词：

HUMAN-BONE-MARROW; IN-VITRO CHONDROGENESIS; UMBILICAL-CORD BLOOD; HUMAN ADIPOSE-TISSUE; MULTI-LINEAGE CELLS; STROMAL CELLS; PROGENITOR CELLS; ARTICULAR CHONDROCYTES; GENE-EXPRESSION; DIFFERENTIAL EXPRESSION;

D O I：

10.1186/scrt31

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from being understood. Different sources of MSCs have been considered for cartilage tissue engineering, mainly based on criteria of availability, as for adipose tissue, or of proximity to cartilage and the joint environment in vivo, as for bone marrow and synovial tissues. Focussing on human MSCs, this review will provide an overview of studies featuring comparative analysis of the chondrogenic differentiation of MSCs from different sources. In particular, it will examine the influence of the cells' origin on the requirements for the induction of chondrogenesis and on the phenotype achieved by the cells after differentiation.

引用

页数：9

共 114 条

[1] A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors [J].

Afizah, Hassan ;

Yang, Zheng ;

Hui, James H. P. ;

Ouyang, Hong-Wei ;

Lee, Eng-Hin .

TISSUE ENGINEERING, 2007, 13 (04) :659-666

[2] Hypoxia, HIFs and bone development [J].

Araldi, Elisa ;

Schipani, Ernestina .

BONE, 2010, 47 (02) :190-196

[3] Epigenetic Signatures Associated with Different Levels of Differentiation Potential in Human Stem Cells [J].

Aranda, Pablo ;

Agirre, Xabier ;

Ballestar, Esteban ;

Andreu, Enrique J. ;

Roman-Gomez, Jose ;

Prieto, Ines ;

Martin-Subero, Jose Ignacio ;

Cigudosa, Juan Cruz ;

Siebert, Reiner ;

Esteller, Manel ;

Prosper, Felipe .

PLOS ONE, 2009, 4 (11)

[4]

BAB I, 1988, BONE MINER, V4, P373

[5] Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes [J].

Barbero, A ;

Ploegert, S ;

Heberer, M ;

Martin, I .

ARTHRITIS AND RHEUMATISM, 2003, 48 (05) :1315-1325

[6] Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components [J].

Barry, F ;

Boynton, RE ;

Liu, BS ;

Murphy, JM .

EXPERIMENTAL CELL RESEARCH, 2001, 268 (02) :189-200

[7] Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2 [J].

Belema-Bedada, Fikru ;

Uchida, Shizuka ;

Martire, Alessandra ;

Kostin, Sawa ;

Braun, Thomas .

CELL STEM CELL, 2008, 2 (06) :566-575

[8] Regulation of the Chondrogenic Phenotype in Culture [J].

Bobick, Brent E. ;

Chen, Faye H. ;

Le, Annie M. ;

Tuan, Rocky S. .

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 2009, 87 (04) :351-371

[9] Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells [J].

Boeuf, Stephane ;

Boerger, Maike ;

Hennig, Thea ;

Winter, Anja ;

Kasten, Philip ;

Richter, Wiltrud .

DIFFERENTIATION, 2009, 78 (2-3) :108-115

[10] TREATMENT OF DEEP CARTILAGE DEFECTS IN THE KNEE WITH AUTOLOGOUS CHONDROCYTE TRANSPLANTATION [J].

BRITTBERG, M ;

LINDAHL, A ;

NILSSON, A ;

OHLSSON, C ;

ISAKSSON, O ;

PETERSON, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (14) :889-895

← 1 2 3 4 5 6 7 8 9 10 →