Subcellular IR Imaging of a Metal-Carbonyl Moiety Using Photothermally Induced Resonance

被引：137

作者：

Policar, Clotilde ^{[1
]}

Waern, Jenny Birgitta ^{[2
]}

Plamont, Marie-Aude ^{[3
]}

Clede, Sylvain ^{[1
]}

Mayet, Celine ^{[4
]}

Prazeres, Rui ^{[4
]}

Ortega, Jean-Michel ^{[4
]}

Vessieres, Anne ^{[3
]}

Dazzi, Alexandre ^{[4
]}

机构：

[1] Univ Paris 06, Lab BioMol, CNRS,UMR7203, Dept Chim ENS, F-75231 Paris 05, France

[2] Univ Paris 11, ICMMO, CNRS, UMR8182, F-91405 Orsay, France

[3] ENSCP, Lab Charles Friedel, UMR7223, F-75231 Paris 05, France

[4] Univ Paris 11, LCP, CNRS, UMR8000, F-91405 Orsay, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 04期

关键词：

imaging agents; IR spectroscopy; metallocenes; spectromicroscopy; subcellular mapping; CYTOTOXICITY; COMPLEXES; ACID; AFM;

D O I：

10.1002/anie.201003161

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some like it hot! The photothermally induced resonance technique, in which an AFM microscope is coupled to a tunable pulsed IR laser, allows IR mapping and gives access to local IR spectra at the subcellular level. A metal-carbonyl compound was internalized in cells and detected in the cell nucleus thanks to its IR signature. The local IR spectrum at the nucleus showed the characteristic IR bands of the {Re(CO)3} unit. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：860 / 864

页数：5

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