Reply to comments on "Highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity"

被引：22

作者：

Haynes, RK ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 14期

关键词：

alkylation; antiviral agents; herne proteins; iron; porphyrinoids;

D O I：

10.1002/anie.200462723

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In light of the discussion on C10-substituted derivatives of the antimalarial agent artemisinin in the preceding correspondence article which relates to his earlier work, R. K. Haynes reiterates here that there is no correlation between the ability of artemisinins to react with heme- or non-heme-FeII and their antimalarial activity. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2064 / 2065

页数：2

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