Terpenoids from Guarea rhophalocarpa

被引：36

作者：

Camacho, MD

Phillipson, JD

Croft, SL

Kirby, GC

Warhurst, DC

Solis, PN

机构：

[1] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

[2] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[3] Univ Panama, Fac Farm, CIFLORPAN, Panama City, Panama

来源：

PHYTOCHEMISTRY | 2001年 / 56卷 / 02期

关键词：

Guarea rhopalocarpa; Meliaceae; leaves; ent-8(14); 15-sandaracopimaradiene-2; alpha; 18-diol; 15-sandacopimaradiene-2; beta; 23-hydroxy-5 alpha-lanosta-7,9(11),24-triene-3-one, and 5 alpha-lanosta-7,9(11),24-triene-3 alpha,23-diol; Leishmania donovani; Trypanosoma brucei brucei; Plasmodium falciparum; KB cells;

D O I：

10.1016/S0031-9422(00)00310-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new terpenes including, two sandaracopimaradiene diterpenoids, ent-8(14),15-sandaracopimaradiene-2 alpha ,18-diol, and ent-8(14),15-sandaracopimaradiene-2 beta ,18-diol, and two lansotane triterpenoids, 23-hydroxy-5 alpha -lanosta 7,9(11),24-triene-3-one, and 5 alpha -lanosta-7,9(11),24-triene-3 alpha .23-diol, were isolated from the methanolic extract prepared from the leaves of G. rhopalocarpa together with the known steroid stigmasterol and the coumarin, scopoletin. The isolates showed weak antiprotozoal activity against Leishmania donovani promastigotes, and Trypanosoma brucei brucei blood stream trypomastigotes, and were devoid of interesting activity towards Plasmodium falciparum. The isolates did not show significant cytotoxic activity against KB cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：203 / 210

页数：8

共 31 条

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