Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors

被引:231
作者
Satoh, AK
O'Tousa, JE
Ozaki, K
Ready, DF [1 ]
机构
[1] Purdue Univ, Dept Sci Biol, W Lafayette, IN 47907 USA
[2] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA
[3] Osaka Univ, Grad Sch Frontier Biosci, Toyonaka, Osaka 5600043, Japan
来源
DEVELOPMENT | 2005年 / 132卷 / 07期
关键词
Rhodopsin; Rab11; retina; Drosophila;
D O I
10.1242/dev.01704
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In developing Drosophila photoreceptors, rhodopsin is trafficked to the rhabdomere, a specialized domain within the apical membrane surface. Rab11, a small GTPase implicated in membrane traffic, immunolocalizes to the trans-Golgi network, cytoplasmic vesicles and tubules, and the base of rhabdomeres. One hour after release from the endoplasmic reticulum, rhodopsin colocalizes with Rab11 in vesicles at the base of the rhabdomere. When Rab11 activity is reduced by three different genetic procedures, rhabdomere morphogenesis is inhibited and rhodopsin-bearing vesicles proliferate within the cytosol. Rab11 activity is also essential for development of MVB endosomal compartments; this is probably a secondary consequence of impaired rhabdomere development. Furthermore, Rab11 is required for transport of TRP, another rhabdomeric protein, and for development of specialized membrane structures within Garland cells. These results establish a role for Rab11 in the post-Golgi transport of rhodopsin and of other proteins to the rhabdomeric membranes of photoreceptors, and in analogous transport processes in other cells.
引用
收藏
页码:1487 / 1497
页数:11
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