Control of gene expression in Plasmodium falciparum

被引：86

作者：

Horrocks, P

Dechering, K

Lanzer, M

机构：

[1] Univ Wurzburg, Zentrum Infekt Forsch, D-97070 Wurzburg, Germany

[2] Univ Nijmegen, Dept Mol Biol, NL-6525 ED Nijmegen, Netherlands

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1998年 / 95卷 / 02期

关键词：

gene expression; Plasmodium falciparum; promoter;

D O I：

10.1016/S0166-6851(98)00110-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfection has facilitated a functional analysis of transcriptional processes in the human malarial parasite Plasmodium falciparum, providing the first fascinating glimpses into the mechanisms regulating parasite development and pathogenicity. Here we review our rapidly evolving knowledge of what constitutes a promoter, what factors regulate promoter activity and how this activity affects the manifestation of the disease. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：171 / 181

页数：11

相关论文

共 91 条

[1] Structure and polymorphism of the upstream region of the pfgZ7/25 gene, transcriptionally regulated in gametocytogenesis of Plasmodium falciparum [J].

Alano, P ;

Silvestrini, F ;

Roca, L .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 79 (02) :207-217

[2] KNOB-POSITIVE AND KNOB-NEGATIVE PLASMODIUM-FALCIPARUM DIFFER IN EXPRESSION OF A STRAIN-SPECIFIC MALARIAL ANTIGEN ON THE SURFACE OF INFECTED ERYTHROCYTES [J].

ALEY, SB ;

SHERWOOD, JA ;

HOWARD, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (05) :1585-1590

[3] Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to CD36, thrombospondin, and intercellular adhesion molecule 1 [J].

Baruch, DI ;

Gormley, JA ;

Ma, C ;

Howard, RJ ;

Pasloske, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) :3497-3502

[4] CLONING THE PLASMODIUM-FALCIPARUM GENE ENCODING PFEMP1, A MALARIAL VARIANT ANTIGEN AND ADHERENCE RECEPTOR ON THE SURFACE OF PARASITIZED HUMAN ERYTHROCYTES [J].

BARUCH, DI ;

PASLOSKE, BL ;

SINGH, HB ;

BI, XH ;

MA, XC ;

FELDMAN, M ;

TARASCHI, TF ;

HOWARD, RJ .

CELL, 1995, 82 (01) :77-87

[5] RNA EDITING IN TRYPANOSOMES [J].

BENNE, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 221 (01) :9-23

[6] MAJOR TRANSCRIPT OF THE FRAMESHIFTED COXLL GENE FROM TRYPANOSOME MITOCHONDRIA CONTAINS 4 NUCLEOTIDES THAT ARE NOT ENCODED IN THE DNA [J].

BENNE, R ;

VANDENBURG, J ;

BRAKENHOFF, JPJ ;

SLOOF, P ;

VANBOOM, JH ;

TROMP, MC .

CELL, 1986, 46 (06) :819-826

[7] IDENTIFICATION OF PLASMODIUM-FALCIPARUM HISTONE-2B AND HISTONE-3 GENES [J].

BENNETT, BJ ;

THOMPSON, J ;

COPPEL, RL .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 70 (1-2) :231-233

[8] TRANSCRIPTS CODING FOR VARIANT SURFACE GLYCOPROTEINS OF TRYPANOSOMA-BRUCEI HAVE A SHORT, IDENTICAL EXON AT THEIR 5' END [J].

BOOTHROYD, JC ;

CROSS, GAM .

GENE, 1982, 20 (02) :281-289

[9]

Borst P, 1997, Behring Inst Mitt, P1

[10] ANTIGENIC VARIATION IN AFRICAN TRYPANOSOMES [J].

BORST, P ;

RUDENKO, G .

SCIENCE, 1994, 264 (5167) :1872-1873

← 1 2 3 4 5 6 7 8 9 10 →