Control of gene expression in Plasmodium falciparum

被引：86

作者：

Horrocks, P

Dechering, K

Lanzer, M

机构：

[1] Univ Wurzburg, Zentrum Infekt Forsch, D-97070 Wurzburg, Germany

[2] Univ Nijmegen, Dept Mol Biol, NL-6525 ED Nijmegen, Netherlands

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1998年 / 95卷 / 02期

关键词：

gene expression; Plasmodium falciparum; promoter;

D O I：

10.1016/S0166-6851(98)00110-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfection has facilitated a functional analysis of transcriptional processes in the human malarial parasite Plasmodium falciparum, providing the first fascinating glimpses into the mechanisms regulating parasite development and pathogenicity. Here we review our rapidly evolving knowledge of what constitutes a promoter, what factors regulate promoter activity and how this activity affects the manifestation of the disease. (C) 1998 Elsevier Science B.V. All rights reserved.

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收藏

页码：171 / 181

页数：11

相关论文

共 91 条

[11] CONTROL OF ANTIGENIC VARIATION IN AFRICAN TRYPANOSOMES [J].

BORST, P ;

GOMMERSAMPT, JH ;

LIGTENBERG, MJL ;

RUDENKO, G ;

KIEFT, R ;

TAYLOR, MC ;

BLUNDELL, PA ;

VANLEEUWEN, F .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1993, 58 :105-114

[12] PLASMODIUM-FALCIPARUM CHROMATIN - NUCLEOSOMAL ORGANIZATION AND HISTONE-LIKE PROTEINS [J].

CARY, C ;

LAMONT, D ;

DALTON, JP ;

DOERIG, C .

PARASITOLOGY RESEARCH, 1994, 80 (03) :255-258

[13] Intraerythrocytic expression of topoisomerase II from Plasmodium falciparum is developmentally regulated [J].

Cheesman, S ;

Horrocks, P ;

Tosh, K ;

Kilbey, B .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 92 (01) :39-46

[14] Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum [J].

Crabb, BS ;

Cowman, AF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :7289-7294

[15] IDENTIFICATION OF A PLASMODIUM-FALCIPARUM HISTONE 2A GENE [J].

CREEDON, KA ;

KASLOW, DC ;

RATHOD, PK ;

WELLEMS, TE .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 54 (01) :113-115

[16] Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase [J].

DarkinRattray, SJ ;

Gurnett, AM ;

Myers, RW ;

Dulski, PM ;

Crumley, TM ;

Allocco, JJ ;

Cannova, C ;

Meinke, PT ;

Colletti, SL ;

Bednarek, MA ;

Singh, SB ;

Goetz, MA ;

Dombrowski, AW ;

Polishook, JD ;

Schmatz, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13143-13147

[17] STAGE-SPECIFIC PROTEIN-SYNTHESIS BY ASEXUAL BLOOD STAGE PARASITES OF PLASMODIUM-KNOWLESI [J].

DEANS, JA ;

THOMAS, AW ;

COHEN, S .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1983, 8 (01) :31-44

[18] Developmentally regulated expression of pfs16, a marker for sexual differentiation of the human malaria parasite Plasmodium falciparum [J].

Dechering, KJ ;

Thompson, J ;

Dodemont, HJ ;

Eling, W ;

Konings, RNH .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 89 (02) :235-244

[19] EXPRESSION OF ALPHA-TUBULIN AND BETA-TUBULIN GENES DURING THE ASEXUAL AND SEXUAL BLOOD STAGES OF PLASMODIUM-FALCIPARUM [J].

DELVES, CJ ;

ALANO, P ;

RIDLEY, RG ;

GOMAN, M ;

HOLLOWAY, SP ;

HYDE, JE ;

SCAIFE, JG .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 43 (02) :271-278

[20] INSTABILITY OF SIMPLE SEQUENCE REPEATS IN A MAMMALIAN-CELL LINE [J].

FARBER, RA ;

PETES, TD ;

DOMINSKA, M ;

HUDGENS, SS ;

LISKAY, RM .

HUMAN MOLECULAR GENETICS, 1994, 3 (02) :253-256

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