Efficient and copper-free Pd(OAc)2/DABCO-catalyzed Sonogashira cross-coupling reaction

被引：60

作者：

Li, JH ^{[1
]}

Zhang, XD ^{[1
]}

Xie, YX ^{[1
]}

机构：

[1] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Coll Chem & Chem Engn, Changsha 410081, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2005年 / 05期

关键词：

Pd(OAc)(2)/DABCO; Sonogashira cross-coupling reaction; aryl halide; terminal alkyne; turnover number;

D O I：

10.1055/s-2005-861805

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and copper-free palladium-catalyzed Sonogashira cross-coupling reaction protocol is presented. In the presence of 3 mol% of Pd(OAc)(2) and 6 mol% of DABCO, cross-coupling of various aryl halides (iodides and bromides) with terminal alkynes afforded the corresponding alkynes in moderate to excellent yields. Moreover, high TONS (turnover numbers, up to 720 000 for the reaction of 1-iodo-4-nitrobenzene with phenylacetylene) for the Sonogashira cross-coupling reaction were observed.

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页码：804 / 808

页数：5

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