Translesion synthesis: Y-farnily polymerases and the polymerase switch

被引：303

作者：

Lehmann, Alan R. ^{[1
]}

Niimi, Atsuko

Ogi, Tomoo

Brown, Stephanie

Sabbioneda, Simone

Wing, Jonathan F.

Kannouche, Patricia L.

Green, Catherine M.

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

[2] Inst Gustave Roussy, CNRS, Lab Genomes & Canc, Villejuif, France

来源：

DNA REPAIR | 2007年 / 6卷 / 07期

基金：

英国医学研究理事会;

关键词：

DNA polymerase; replication factories; PCNA; ubiquitination;

D O I：

10.1016/j.dnarep.2007.02.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks. (C) 2007 Published by Elsevier B.V.

引用

页码：891 / 899

页数：9

共 98 条

[21] Trading places: How do DNA polymerases switch during translesion DNA synthesis? [J].

Friedberg, EC ;

Lehmann, AR ;

Fuchs, RPP .

MOLECULAR CELL, 2005, 18 (05) :499-505

[22] Suffering in silence: The tolerance of DNA damage [J].

Friedberg, EC .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (12) :943-953

[23] Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases η and REV1 [J].

Garg, P ;

Burgers, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (51) :18361-18366

[24] The relative roles in vivo of Saccharomyces cerevisiae Pol η, Pol ξ, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (64) photoadduct and T-T cis-syn cyclobutane dimer [J].

Gibbs, PEM ;

McDonald, J ;

Woodgate, R ;

Lawrence, CW .

GENETICS, 2005, 169 (02) :575-582

[25] A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ [J].

Gibbs, PEM ;

McGregor, WG ;

Maher, VM ;

Nisson, P ;

Lawrence, CW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6876-6880

[26] The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light [J].

Gibbs, PEM ;

Wang, XD ;

Li, ZQ ;

McManus, TP ;

McGregor, WG ;

Lawrence, CW ;

Maher, VM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4186-4191

[27] Error-prone repair DNA polymerases in prokaryotes and eukaryotes [J].

Goodman, MF .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :17-50

[28] REV1 protein interacts with PCNA: Significance of the REV1 BRCT domain in vitro and in vivo [J].

Guo, Caixia ;

Sonoda, Eiichiro ;

Tang, Tie-Shan ;

Parker, Joanne L. ;

Bielen, Aleksandra B. ;

Takeda, Shunichi ;

Ulrich, Helle D. ;

Friedberg, Errol C. .

MOLECULAR CELL, 2006, 23 (02) :265-271

[29] Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis [J].

Guo, CX ;

Fischhaber, PL ;

Luk-Paszyc, MJ ;

Masuda, Y ;

Zhou, J ;

Kamiya, K ;

Kisker, C ;

Friedberg, EC .

EMBO JOURNAL, 2003, 22 (24) :6621-6630

[30] Replication fork reactivation downstream of a blocked nascent leading strand [J].

Heller, RC ;

Marians, KJ .

NATURE, 2006, 439 (7076) :557-562

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