Clinical Predictors of Mortality in Patients With Ebola Virus Disease

被引:30
作者
Barry, Moumie [1 ]
Toure, Abdoulaye [2 ]
Traore, Fode Amara [1 ,3 ]
Sako, Fode-Bangaly [1 ]
Sylla, Djibril [4 ]
Kpamy, Dimai Ouo [1 ]
Bah, Elhadj Ibrahima [1 ]
Bangoura, M'Mah [1 ]
Poncin, Marc [5 ]
Keita, Sakoba [6 ]
Tounkara, Thierno Mamadou [2 ]
Cisse, Mohamed [2 ]
Vanhems, Philippe [7 ,8 ]
机构
[1] Hop Natl Donka, Serv Malad Infect & Trop, Conakry, Guinea
[2] Univ Conakry, CHU Conakry, Chaire Sante Publ, Dept Pharm, Conakry, Guinea
[3] Univ Conakry, CHU Conakry, Chaire Dermatol & Malad Infect, Conakry, Guinea
[4] Univ Conakry, CHU Conakry, Chaire Med Interne, Conakry, Guinea
[5] Med Sans Frontieres Belgique, Conakry, Guinea
[6] Minist Sante Publ, Div Prevent & Lutte Malad, Conakry, Guinea
[7] Hosp Civils Lyon, Hop Edouard Herriot, Serv Hyg Hosp Epidemiol & Prevent, Lyon, France
[8] Univ Lyon 1, F-69622 Villeurbanne, France
关键词
Ebola virus disease; hemorrhagic fever; mortality; HEMORRHAGIC-FEVER; WEST-AFRICA; CONGO; OUTBREAK; KIKWIT; EPIDEMIC; UGANDA;
D O I
10.1093/cid/civ202
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In an observational cohort study including 89 Ebola patients, predictive factors of death were analyzed. The crude mortality rate was 43.8%. Myalgia (adjusted odds ratio [OR], 4.04; P = .02), hemorrrhage (adjusted OR, 3.5; P = .02), and difficulty breathing (adjusted OR, 5.75; P = .01) were independently associated with death.
引用
收藏
页码:1821 / 1824
页数:4
相关论文
共 16 条
[1]   Ebola Virus Disease in West Africa - The First 9 Months of the Epidemic and Forward Projections [J].
Aylward, Bruce ;
Barboza, Philippe ;
Bawo, Luke ;
Bertherat, Eric ;
Bilivogui, Pepe ;
Blake, Isobel ;
Brennan, Rick ;
Briand, Sylvie ;
Chakauya, Jethro Magwati ;
Chitala, Kennedy ;
Conteh, Roland M. ;
Cori, Anne ;
Croisier, Alice ;
Dangou, Jean-Marie ;
Diallo, Boubacar ;
Donnelly, Christl A. ;
Dye, Christopher ;
Eckmanns, Tim ;
Ferguson, Neil M. ;
Formenty, Pierre ;
Fuhrer, Caroline ;
Fukuda, Keiji ;
Garske, Tini ;
Gasasira, Alex ;
Gbanyan, Stephen ;
Graaff, Peter ;
Heleze, Emmanuel ;
Jambai, Amara ;
Jombart, Thibaut ;
Kasolo, Francis ;
Kadiobo, Albert Mbule ;
Keita, Sakoba ;
Kertesz, Daniel ;
Kone, Moussa ;
Lane, Chris ;
Markoff, Jered ;
Massaquoi, Moses ;
Mills, Harriet ;
Mulba, John Mike ;
Musa, Emmanuel ;
Myhre, Joel ;
Nasidi, Abdusalam ;
Nilles, Eric ;
Nouvellet, Pierre ;
Nshimirimana, Deo ;
Nuttall, Isabelle ;
Nyenswah, Tolbert ;
Olu, Olushayo ;
Pendergast, Scott ;
Perea, William .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (16) :1481-1495
[2]   Emergence of Zaire Ebola Virus Disease in Guinea [J].
Baize, Sylvain ;
Pannetier, Delphine ;
Oestereich, Lisa ;
Rieger, Toni ;
Koivogui, Lamine ;
Magassouba, N'Faly ;
Soropogui, Barre ;
Sow, Mamadou Saliou ;
Keita, Sakoba ;
De Clerck, Hilde ;
Tiffany, Amanda ;
Dominguez, Gemma ;
Loua, Mathieu ;
Traore, Alexis ;
Kolie, Moussa ;
Malano, Emmanuel Roland ;
Heleze, Emmanuel ;
Bocquin, Anne ;
Mely, Stephane ;
Raoul, Herve ;
Caro, Valerie ;
Cadar, Daniel ;
Gabriel, Martin ;
Pahlmann, Meike ;
Tappe, Dennis ;
Schmidt-Chanasit, Jonas ;
Impouma, Benido ;
Diallo, Abdoul Karim ;
Formenty, Pierre ;
Van Herp, Michel ;
Guenther, Stephan .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (15) :1418-1425
[3]   Unrecognized Ebola hemorrhagic fever at Mosango Hospital during the 1995 epidemic in Kikwit, Democratic Republic of the Congo [J].
Bonnet, MJ ;
Akamituna, P ;
Mazaya, A .
EMERGING INFECTIOUS DISEASES, 1998, 4 (03) :508-510
[4]   Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: Clinical observations in 103 patients [J].
Bwaka, MA ;
Bonnet, MJ ;
Calain, P ;
Colebunders, R ;
De Roo, A ;
Guimard, Y ;
Katwiki, KR ;
Kibadi, K ;
Kipasa, MA ;
Kuvula, KJ ;
Mapanda, BB ;
Massamba, M ;
Mupapa, KD ;
Muyembe-Tamfum, JJ ;
Ndaberey, E ;
Peters, CJ ;
Rollin, PE ;
Van den Enden, E .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S1-S7
[5]   Ebola - A Growing Threat? [J].
Feldmann, Heinz .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (15) :1375-1378
[6]   Ebola haemorrhagic fever [J].
Feldmann, Heinz ;
Geisbert, Thomas W. .
LANCET, 2011, 377 (9768) :849-862
[7]   Caring for Critically Ill Patients with Ebola Virus Disease Perspectives from West Africa [J].
Fowler, Robert A. ;
Fletcher, Thomas ;
Fischer, William A., II ;
Lamontagne, Francois ;
Jacob, Shevin ;
Brett-Major, David ;
Lawler, James V. ;
Jacquerioz, Frederique A. ;
Houlihan, Catherine ;
O'Dempsey, Tim ;
Ferri, Mauricio ;
Adachi, Takuya ;
Lamah, Marie-Claire ;
Bah, Elhadj Ibrahima ;
Mayet, Thierry ;
Schieffelin, John ;
McLellan, Susan L. ;
Senga, Mikiko ;
Kato, Yasuyuki ;
Clement, Christophe ;
Mardel, Simon ;
De Villar, Rosa Constanza Vallenas Bejar ;
Shindo, Nahoko ;
Bausch, Daniel .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (07) :733-737
[8]   Epidemiological Dynamics of Ebola Outbreaks [J].
House, Thomas .
ELIFE, 2014, 3 :e03908
[9]   Case fatality rates of Ebola virus diseases: A meta-analysis of World Health Organization data [J].
Lefebvre, A. ;
Fiet, C. ;
Belpois-Duchamp, C. ;
Tiv, M. ;
Astruc, K. ;
Glele, L. S. Aho .
MEDECINE ET MALADIES INFECTIEUSES, 2014, 44 (09) :412-416
[10]   Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda [J].
MacNeil, Adam ;
Farnon, Eileen C. ;
Wamala, Joseph ;
Okware, Sam ;
Cannon, Deborah L. ;
Reed, Zachary ;
Towner, Jonathan S. ;
Tappero, Jordan W. ;
Lutwama, Julius ;
Downing, Robert ;
Nichol, Stuart T. ;
Ksiazek, Thomas G. ;
Rollin, Pierre E. .
EMERGING INFECTIOUS DISEASES, 2010, 16 (12) :1969-1972