Crystal structure of the unliganded retinoblastoma protein pocket domain

被引:14
作者
Balog, Eva Rose M. [2 ]
Burke, Jason R. [1 ]
Hura, Greg L. [3 ]
Rubin, Seth M. [1 ]
机构
[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA
[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA
基金
美国国家卫生研究院;
关键词
retinoblastoma protein; tumor-suppressor protein; cell cycle; transcription regulation; protein-protein interactions; X-ray structure; TUMOR-SUPPRESSOR; MOLECULAR-BASIS; E2F; INACTIVATION; GENE;
D O I
10.1002/prot.23007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:2010 / 2014
页数:5
相关论文
共 20 条
[1]  
ADAMS PD, ACTA CRYSTALLOGR D 2, V66, P213
[2]   Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding [J].
Burke, Jason R. ;
Deshong, Alison J. ;
Pelton, Jeffrey G. ;
Rubin, Seth M. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (21) :16286-16293
[3]   Cellular mechanisms of tumour suppression by the retinoblastoma gene [J].
Burkhart, Deborah L. ;
Sage, Julien .
NATURE REVIEWS CANCER, 2008, 8 (09) :671-682
[4]   Coot:: model-building tools for molecular graphics [J].
Emsley, P ;
Cowtan, K .
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2004, 60 :2126-2132
[5]   Conformational changes observed in enzyme crystal structures upon substrate binding [J].
Gutteridge, A ;
Thornton, J .
JOURNAL OF MOLECULAR BIOLOGY, 2005, 346 (01) :21-28
[6]   Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1 [J].
Harbour, JW ;
Luo, RX ;
Santi, AD ;
Postigo, AA ;
Dean, DC .
CELL, 1999, 98 (06) :859-869
[7]   IDENTIFICATION OF HEAVY-ATOM DERIVATIVES BY NORMAL PROBABILITY METHODS [J].
HOWELL, PL ;
SMITH, GD .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1992, 25 :81-86
[8]   Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS) [J].
Hura, Greg L. ;
Menon, Angeli L. ;
Hammel, Michal ;
Rambo, Robert P. ;
Poole, Farris L., II ;
Tsutakawa, Susan E. ;
Jenney, Francis E., Jr. ;
Classen, Scott ;
Frankel, Kenneth A. ;
Hopkins, Robert C. ;
Yang, Sung-jae ;
Scott, Joseph W. ;
Dillard, Bret D. ;
Adams, Michael W. W. ;
Tainer, John A. .
NATURE METHODS, 2009, 6 (08) :606-U83
[9]   Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen [J].
Kim, HY ;
Ahn, BY ;
Cho, Y .
EMBO JOURNAL, 2001, 20 (1-2) :295-304
[10]   Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor [J].
Lee, C ;
Chang, JH ;
Lee, HS ;
Cho, YJ .
GENES & DEVELOPMENT, 2002, 16 (24) :3199-3212