Synthesis of new cationic lipids from an unsaturated glycoside scaffold

被引：17

作者：

Herscovici, J

Egron, MJ

Quenot, A

Leclercq, F

Leforestier, N

Mignet, N

Wetzer, B

Scherman, D

机构：

[1] ENSCP 11, ENSCP Aventis Gencell, CNRS, UMR 7001,LCBBMC, F-75231 Paris, France

[2] Aventis Gencell CRVA13, F-94403 Vitry Sur Seine, France

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 12期

关键词：

D O I：

10.1021/ol0159423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.

引用

页码：1893 / 1896

页数：4

共 25 条

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