The role of peroxisomes in aging

被引:50
作者
Périchon, R
Bourre, JM
Kelly, JF
Roth, GS
机构
[1] NIA, Cellular & Mol Biol Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA
[2] Hop Fernand Widal, Lab Neuro Pharmaco Nutr, INSERM, U26, F-75475 Paris 10, France
关键词
peroxisome; aging; lipid metabolism; oxidative stress;
D O I
10.1007/s000180050192
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reactive oxygen species and alterations in membrane lipid homeostasis are thought to be important events in aging process and aging-related degenerative diseases. The peroxisome is a small cellular organelle involved in both oxygen and lipid metabolism, and defects in peroxisomal function are associated with major, and often fatal, changes at the neurological level during human development. Recent reports of aging-related changes in peroxisomal function raised the hypothesis that peroxisomes may also have a significant role in the aging process and aging-related degenerative diseases. This review presents the current data on changes in peroxisomal function during aging and discusses the implications of these changes for health.
引用
收藏
页码:641 / 652
页数:12
相关论文
共 117 条
[1]   URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].
AMES, BN ;
CATHCART, R ;
SCHWIERS, E ;
HOCHSTEIN, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862
[2]  
ANGERMULLER S, 1987, EUR J CELL BIOL, V45, P137
[3]   PHOSPHOLIPID SPECIES CONTAINING LONG AND VERY LONG POLYENOIC FATTY-ACIDS REMAIN WITH RHODOPSIN AFTER HEXANE EXTRACTION OF PHOTORECEPTOR-MEMBRANES [J].
AVELDANO, MI .
BIOCHEMISTRY, 1988, 27 (04) :1229-1239
[4]  
AVELDANO MI, 1987, J BIOL CHEM, V262, P1180
[5]   PEROXISOMAL-MICROSOMAL COMMUNICATION IN UNSATURATED FATTY-ACID METABOLISM [J].
BAYKOUSHEVA, SP ;
LUTHRIA, DL ;
SPRECHER, H .
FEBS LETTERS, 1995, 367 (02) :198-200
[6]   OXIDATION OF OXALATE AND POLYAMINES BY RAT PEROXISOMES [J].
BEARD, ME ;
BAKER, R ;
CONOMOS, P ;
PUGATCH, D ;
HOLTZMAN, E .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1985, 33 (05) :460-464
[7]   THE IMPACT OF AGING ON ENZYME PROTEINS OF RAT-LIVER PEROXISOMES - QUANTITATIVE-ANALYSIS BY IMMUNOBLOTTING AND IMMUNOELECTRON MICROSCOPY [J].
BEIER, K ;
VOLKL, A ;
FAHIMI, HD .
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1993, 63 (03) :139-146
[8]   DIETARY DEFICIENCY OF DOCOSAHEXAENOIC ACID IMPAIRS VISION AT LOW-LIGHT INTENSITIES IN JUVENILE HERRING (CLUPEA-HARENGUS L) [J].
BELL, MV ;
BATTY, RS ;
DICK, JR ;
FRETWELL, K ;
NAVARRO, JC ;
SARGENT, JR .
LIPIDS, 1995, 30 (05) :443-449
[9]   ALPHA-LINOLENIC ACID DEFICIENCY IN MAN - EFFECT OF ETHYL LINOLENATE ON PLASMA AND ERYTHROCYTE FATTY-ACID COMPOSITION AND BIOSYNTHESIS OF PROSTANOIDS [J].
BJERVE, KS ;
FISCHER, S ;
ALME, K .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1987, 46 (04) :570-576
[10]  
BORDONI A, 1988, BIOCHEM INT, V17, P1001