Isolation of cytotoxic metabolites from targeted Peruvian amazonian medicinal plants

被引：26

作者：

Aponte, Jose C. ^{[1
]}

Vaisberg, Abraham J. ^{[2
]}

Rojas, Rosario ^{[3
]}

Caviedes, Luz ^{[2
]}

Lewis, Walter H. ^{[4
]}

Lamas, Gerardo ^{[5
]}

Sarasara, Csar ^{[6
]}

Gilman, Robert H. ^{[2
,7
]}

Hammond, Gerald B. ^{[1
]}

机构：

[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

[2] Univ Peruana Cayetano Heredia, Dept Microbiol & Lab Invest & Desarrollo, Lima, Peru

[3] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Dept Ciencias Farmaceut, Lima, Peru

[4] Washington Univ, Dept Biol, St Louis, MO 63130 USA

[5] Univ Nacl Mayor San Marcos, Dept Entomol, Museo Hist Nat, Lima 14, Peru

[6] CONAP, Lima, Peru

[7] Johns Hopkins Univ, Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 01期

关键词：

D O I：

10.1021/np070560c

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2',4'-dihydroxy-6'-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

引用

页码：102 / 105

页数：4

共 40 条

[1]

Triterpenes and anthraquinones from Picramnia sellowii Planchon in Hook (Simaroubaceae) [J].

Balderrama, L ;

Braca, A ;

Garcia, E ;

Melgarejo, M ;

Pizza, C ;

De Tommasi, N .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2001, 29 (03) :331-333

[2]

SOME PRACTICAL CONSIDERATIONS AND APPLICATIONS OF THE NATIONAL-CANCER-INSTITUTE IN-VITRO ANTICANCER DRUG DISCOVERY SCREEN [J].

BOYD, MR ;

PAULI, KD .

DRUG DEVELOPMENT RESEARCH, 1995, 34 (02) :91-109

[3]

Tetrazolium microplate assay as a rapid and inexpensive colorimetric method for determination of antibiotic susceptibility of Mycobacterium tuberculosis [J].

Caviedes, L ;

Delgado, J ;

Gilman, RH .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (05) :1873-1874

[4]

Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368 [J].

Chatterjee, P ;

Kouzi, SA ;

Pezzuto, JM ;

Hamann, MT .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (09) :3850-3855

[5]

THE ANTHRAQUINONES OF HETERODERMIA-OBSCURATA [J].

COHEN, PA ;

TOWERS, GHN .

PHYTOCHEMISTRY, 1995, 40 (03) :911-915

[6]

THE CHEMISTRY OF COLOMBIAN MYRISTICACEAE .11. IRYANTHERINS, LIGNOFLAVONOIDS OF NOVEL STRUCTURAL TYPES FROM THE MYRISTICACEAE [J].

CONSERVA, LM ;

YOSHIDA, M ;

GOTTLIEB, OR ;

MARTINEZ, JC ;

GOTTLIEB, HE .

PHYTOCHEMISTRY, 1990, 29 (12) :3911-3918

[7]

Anti-HIV-1 phorbol esters from the seeds of Croton tiglium [J].

El-Mekkawy, S ;

Meselhy, MR ;

Nakamura, N ;

Hattori, M ;

Kawahata, T ;

Otake, T .

PHYTOCHEMISTRY, 2000, 53 (04) :457-464

[8]

The unambiguous detection of kaurenic derivatives in aqueous infusions of Montanoa tomentosa by GC-MS and 2D-NMR spectroscopy: An answer to contradictory reports [J].

Enriquez, RG ;

Miranda, E ;

Ortiz, B ;

Leon, I ;

Magos, G ;

Pena, A ;

Reynolds, WF ;

Gnecco, D .

PLANTA MEDICA, 1996, 62 (06) :569-571

[9]

FANSHAWE DB, 1945, FORESTRY B, V2, P51

[10]

PICRAMNIACEAE, A NEW FAMILY, AND A RECIRCUMSCRIPTION OF SIMAROUBACEAE [J].

FERNANDO, ES ;

QUINN, CJ .

TAXON, 1995, 44 (02) :177-181

← 1 2 3 4 →