Isolation of cytotoxic metabolites from targeted Peruvian amazonian medicinal plants

被引:26
作者
Aponte, Jose C. [1 ]
Vaisberg, Abraham J. [2 ]
Rojas, Rosario [3 ]
Caviedes, Luz [2 ]
Lewis, Walter H. [4 ]
Lamas, Gerardo [5 ]
Sarasara, Csar [6 ]
Gilman, Robert H. [2 ,7 ]
Hammond, Gerald B. [1 ]
机构
[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA
[2] Univ Peruana Cayetano Heredia, Dept Microbiol & Lab Invest & Desarrollo, Lima, Peru
[3] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Dept Ciencias Farmaceut, Lima, Peru
[4] Washington Univ, Dept Biol, St Louis, MO 63130 USA
[5] Univ Nacl Mayor San Marcos, Dept Entomol, Museo Hist Nat, Lima 14, Peru
[6] CONAP, Lima, Peru
[7] Johns Hopkins Univ, Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 01期
关键词
D O I
10.1021/np070560c
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2',4'-dihydroxy-6'-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.
引用
收藏
页码:102 / 105
页数:4
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