A Highly Para-Selective Copper(II)-Catalyzed Direct Arylation of Aniline and Phenol Derivatives

被引：300

作者：

Ciana, Claire-Lise ^{[1
]}

Phipps, Robert J. ^{[1
]}

Brandt, Jochen R. ^{[1
]}

Meyer, Falco-Magnus ^{[1
]}

Gaunt, Matthew J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

aromatic substitution; C-H arylation; copper; hypervalent iodine; synthetic methods; C-H BOND; CATALYZED DIRECT ARYLATION; DIARYLIODONIUM SALTS; UNACTIVATED ARENES; ARYL HALIDES; ACTIVATION; FUNCTIONALIZATION; TRIFLUOROMETHYLATION; SUBSTITUTION; HETEROARENES;

D O I：

10.1002/anie.201004703

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In short order: A copper-catalyzed Friedel-Crafts-type strategy has been developed for the title reaction. An iterative C-H arylation strategy has also been demonstrated for the functionalization of anilines by sequentially delivering different aromatic groups to the para, ortho, and meta positions (see scheme, Bn=benzyl, Piv=pivaloyl). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：458 / 462

页数：5

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