Labeling of mesenchymal stem cells by bioconjugated quantum dots

被引：121

作者：

Shah, Lhranti S.

Clark, Paul A.

Moioli, Eduardo K.

Stroscio, Michael A.

Mao, Jeremy J. ^{[1
]}

机构：

[1] Columbia Univ, Fu Fdn Sch Engn & Appl Sci, Dept Biomed Engn, Coll Dent Med, New York, NY 10032 USA

[2] Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USA

[3] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA

来源：

NANO LETTERS | 2007年 / 7卷 / 10期

关键词：

D O I：

10.1021/nl071547f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Long-term labeling of stem cells during self-replication and differentiation benefits investigations of development and tissue regeneration. We report the labeling of human mesenchymal stem cells (hMSCs) with RGD-conjugated quantum dots (QDs) during self-replication, and multilineage differentiations into osteogenic, chondrogenic, and adipogenic cells. QD-labeled hMSCs remained viable as unlabeled hMSCs from the same subpopulation. These findings suggest the use of bioconjugated QDs as an effective probe for long-term labeling of stem cells.

引用

收藏

页码：3071 / 3079

页数：9

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