Solvent-free synthesis of cyanohydrin derivatives catalysed by triethylamine

被引：65

作者：

Baeza, A

Nájera, C

Retamosa, MD

Sansano, JM

机构：

[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, E-03080 Alicante, Spain

[2] Univ Alicante, Fac Ciencias, ISO, E-03080 Alicante, Spain

来源：

SYNTHESIS-STUTTGART | 2005年 / 16期

关键词：

addition reactions; catalysis; cyanohydrin derivatives; green chemistry; solvent-free reactions;

D O I：

10.1055/s-2005-872096

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very simple one-step environmentally friendly procedure for the synthesis of 0-substituted cyanohydrins from aldehydes and ketones, in the absence of solvent, employing minimum amounts of the corresponding cyanides has been optimised. Aldehydes react more rapidly than ketones using triethylamine as catalyst offering in both cases almost quantitative yields of the corresponding 0-trimethylsilyl, 0-methoxycarbonyl, 0-benzoyl and 0-acetyl cyanohydrins.

引用

页码：2787 / 2797

页数：11

共 66 条

[41] Highly enantioselective cyanosilylation of aldehydes catalyzed by novel β-amino alcohol-titanium complexes [J].