Genetics of aging in Caenorhabditis elegans

被引:150
作者
Antebi, Adam
机构
[1] Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
来源
PLOS GENETICS | 2007年 / 3卷 / 09期
关键词
D O I
10.1371/journal.pgen.0030129
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen. © 2007 Adam Antebi.
引用
收藏
页码:1565 / 1571
页数:7
相关论文
共 132 条
[1]   Neurosecretory control of aging in Caenorhabditis elegans [J].
Ailion, M ;
Inoue, T ;
Weaver, CI ;
Holdcraft, RW ;
Thomas, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) :7394-7397
[2]   Regulation of C-elegans longevity by specific gustatory and olfactory neurons [J].
Alcedo, J ;
Kenyon, C .
NEURON, 2004, 41 (01) :45-55
[3]   SKN-1 links C-elegans mesendodermal specification to a conserved oxidative stress response [J].
An, JH ;
Blackwell, TK .
GENES & DEVELOPMENT, 2003, 17 (15) :1882-1893
[4]   The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans [J].
Apfeld, J ;
O'Connor, G ;
McDonagh, T ;
DiStefano, PS ;
Curtis, R .
GENES & DEVELOPMENT, 2004, 18 (24) :3004-3009
[5]   Regulation of lifespan by sensory perception in Caenorhabditis elegans [J].
Apfeld, J ;
Kenyon, C .
NATURE, 1999, 402 (6763) :804-809
[6]   Regulation of life-span by germ-line stem cells in Caenorhabditis elegans [J].
Arantes-Oliveira, N ;
Apfeld, J ;
Dillin, A ;
Kenyon, C .
SCIENCE, 2002, 295 (5554) :502-505
[7]   Resveratrol improves health and survival of mice on a high-calorie diet [J].
Baur, Joseph A. ;
Pearson, Kevin J. ;
Price, Nathan L. ;
Jamieson, Hamish A. ;
Lerin, Carles ;
Kalra, Avash ;
Prabhu, Vinayakumar V. ;
Allard, Joanne S. ;
Lopez-Lluch, Guillermo ;
Lewis, Kaitlyn ;
Pistell, Paul J. ;
Poosala, Suresh ;
Becker, Kevin G. ;
Boss, Olivier ;
Gwinn, Dana ;
Wang, Mingyi ;
Ramaswamy, Sharan ;
Fishbein, Kenneth W. ;
Spencer, Richard G. ;
Lakatta, Edward G. ;
Le Couteur, David ;
Shaw, Reuben J. ;
Navas, Placido ;
Puigserver, Pere ;
Ingram, Donald K. ;
de Cabo, Rafael ;
Sinclair, David A. .
NATURE, 2006, 444 (7117) :337-342
[8]   C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span [J].
Berdichevsky, Ala ;
Viswanathan, Mohan ;
Horvitz, H. Robert ;
Guarente, Leonard .
CELL, 2006, 125 (06) :1165-1177
[9]   Germ-cell loss extends C-elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling [J].
Berman, JR ;
Kenyon, C .
CELL, 2006, 124 (05) :1055-1068
[10]   Two neurons mediate diet-restriction-induced longevity in C-elegans [J].
Bishop, Nicholas A. ;
Guarente, Leonard .
NATURE, 2007, 447 (7144) :545-+