WNT signalling in the immune system: WNT is spreading its wings

被引：453

作者：

Staal, Frank J. T. ^{[1
]}

Luis, Tiago C. ^{[1
]}

Tiemessen, Machteld M. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Immunol, NL-3015 GE Rotterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 08期

关键词：

D O I：

10.1038/nri2360

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

WNT proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. In blood and immune cells, WNT signalling controls the proliferation of progenitor cells and might also affect the cell-fate decisions of stem cells. Recent studies indicate that WNT proteins also regulate effector T-cell development, regulatory T-cell activation and dendritic-cell maturation. WNT signalling seems to function as a universal mechanism in leukocytes to establish a pool of undifferentiated cells for further selection, effector-cell maturation and terminal differentiation. WNT signalling is therefore subject to strict molecular control, and dysregulated WNT signalling is implicated in the development of haematological malignancies.

引用

页码：581 / 593

页数：13

共 112 条

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