Numerical and experimental investigation of the diffusional release of a dispersed solute from polymeric multilaminate matrices

In the present work the release behavior of special, multilaminate matrix-type polymer systems, is studied both theoretically and experimentally. Two different mathematical models have been employed to describe the release of a dispersed solute from both single- and multilayer matrices. A parameter sensitivity study shows that the incorporation of supersaturated matrices in the formation of multilaminate devices, with a nonuniform initial solute loading, can provide a delivery system with optimized performance compared to monolithic ones. Finally, the findings of this theoretical analysis show,good agreement with measurements of the release rates of a model disperse dye from both single- and multilayer matrices. (C) 2001 Published by Elsevier Science B.V.