Structure-selectivity studies on catalysts for the phase-transfer catalysed asymmetric alkylation of glycine imine esters

被引：65

作者：

Lygo, B ^{[1
]}

Crosby, J

Lowdon, TR

Wainwright, PG

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] AstraZeneca, Proc R&D, Macclesfield SK10 2NA, Cheshire, England

[3] Hickson & Welch Ltd, Castleford WF10 2JT, W Yorkshire, England

[4] Univ Salford, Dept Chem, Salford M5 4WT, Lancs, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 12期

关键词：

cinchona alkaloid; phase-transfer; asymmetric catalysis; amino acid;

D O I：

10.1016/S0040-4020(01)00093-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we describe the synthesis of a series of chiral quaternary ammonium salts with core structures that are closely related to the cinchona alkaloid, cinchonine. By employing these salts as asymmetric phase-transfer agents in the benzylation of a glycine imine, an optimal catalyst structure is identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2391 / 2402

页数：12

共 38 条

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