Marine actinobacteria: new opportunities for natural product search and discovery

被引：282

作者：

Bull, Alan T. ^{[1
]}

Stach, James E. M. ^{[2
]}

机构：

[1] Univ Kent, Dept Biosci, Canterbury CT2 7NJ, Kent, England

[2] Newcastle Univ, Inst Res Environm & Sustainabil, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

TRENDS IN MICROBIOLOGY | 2007年 / 15卷 / 11期

关键词：

D O I：

10.1016/j.tim.2007.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is widely accepted that new drugs, especially antibiotics, are urgently required, and that the most propitious source remains natural products. We argue that in exploring new sources of bioactive natural products the marine environment warrants particular attention, in view of the remarkable diversity of microorganisms and metabolic products. Recent reports of new chemical entities and first-in-class drug candidates, and confirmation of indigenous marine actinobacteria, make exciting discoveries even more likely given the unrivalled capacity of this class of bacteria to produce exploitable natural products.

引用

页码：491 / 499

页数：9

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