Multilayer DNA Origami Packed on Hexagonal and Hybrid Lattices

被引：106

作者：

Ke, Yonggang ^{[1
,2
]}

Voigt, Niels V. ^{[4
,5
]}

Gothelf, Kurt V. ^{[4
,5
]}

Shih, William M. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] Harvard, Wyss Inst Biol Inspired Engn, Cambridge, MA 02138 USA

[4] Aarhus Univ, Danish Natl Res Fdn, Interdisciplinary Nanosci Ctr iNANO, Ctr DNA Nanotechnol, DK-8000 Aarhus, Denmark

[5] Aarhus Univ, Dept Chem, DK-8000 Aarhus, Denmark

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

FOLDING DNA; SHAPES;

D O I：

10.1021/ja209719k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

"Scaffolded DNA origami" has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher resolution of spatial addressing than has been shown previously. We also demonstrate hybrid multilayer DNA origami with honeycomb-lattice, square-lattice, and hexagonal-lattice packing of helices all in one design. The availability of hexagonal close-packing of helices extends our ability to build complex structures using DNA nanotechnology.

引用

页码：1770 / 1774

页数：5

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