The amyloid cascade hypothesis

被引：97

作者：

Korczyn, Amos D. ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Sieratzki Chair Neurol, IL-69978 Tel Aviv, Israel

来源：

ALZHEIMERS & DEMENTIA | 2008年 / 4卷 / 03期

关键词：

D O I：

10.1016/j.jalz.2007.11.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The amyloid deposits in the brains of patients with Alzheimer's disease have attracted attention and are now considered not only an essential requirement for pathological diagnosis but also an important clue to the pathogenesis of the disease. This article looks critically at the basis of the "amyloid cascade hypothesis" to conclude that there are many issues that need to be resolved since they are inconsistent with the hypothesis. (C) 2008 The Alzheimer's Association. All rights reserved.

引用

页码：176 / 178

页数：3

共 21 条

[11] Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ1-40 and Aβ1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "γ-secretase" [J].

Ikeuchi, T ;

Dolios, G ;

Kim, SH ;

Wang, R ;

Sisodia, SS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (09) :7010-7018

[12]

IQBAL K, 1996, ALZHEIMERS DIS MOL B, P31

[13] β-amyloid therapies in Alzheimer's disease [J].

Jhee, S ;

Shiovitz, T ;

Crawford, AW ;

Cutler, NR .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (04) :593-605

[14] Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques [J].

Koistinaho, M ;

Ort, M ;

Cimadevilla, JM ;

Vondrous, R ;

Cordell, B ;

Koistinaho, J ;

Bures, J ;

Higgins, LS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14675-14680

[15] Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice [J].

Levi, Ofir ;

Michaelson, Daniel M. .

JOURNAL OF NEUROCHEMISTRY, 2007, 100 (01) :202-210

[16] Immunization therapy in Alzheimer's disease [J].

Mor, Felix ;

Monsonego, Alon .

EXPERT REVIEW OF NEUROTHERAPEUTICS, 2006, 6 (05) :653-659

[17] Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide:: a case report [J].

Nicoll, JAR ;

Wilkinson, D ;

Holmes, C ;

Steart, P ;

Markham, H ;

Weller, RO .

NATURE MEDICINE, 2003, 9 (04) :448-452

[18]

Ohno M, 2006, REV NEUROSCIENCE, V17, P429

[19] Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury [J].

Ponsford, Jennie ;

Rudzki, Dion ;

Bailey, Karen ;

Ng, Kim T. .

NEUROLOGY, 2007, 68 (08) :619-620

[20] Aβ42 gene vaccination reduces brain amyloid plaque burden in transgenic mice [J].

Qu, Baoxi ;

Boyer, Philip J. ;

Johnston, Stephen Albert ;

Hynan, Linda S. ;

Rosenberg, Roger N. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2006, 244 (1-2) :151-158

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