Primary colorectal small cell carcinoma: A clinicopathological and immunohistochemical study of 10 cases

被引：12

作者：

El Demellawy, Dina ^{[2
]}

Khalifa, Mahmoud A. ^{[1
]}

Ismiil, Nadia ^{[1
]}

Wong, Shun ^{[3
]}

Ghorab, Zeina ^{[1
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Dept Pathol, Toronto, ON M4N 3M5, Canada

[2] Thunder Bay Reg Hlth Sci Ctr, Dept Pathol, Thunder Bay, ON P7G 1P1, Canada

[3] Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON M4N 3M5, Canada

来源：

DIAGNOSTIC PATHOLOGY | 2007年 / 2卷 / 1期

关键词：

Adenoma; Small Cell Carcinoma; Colorectal Adenocarcinoma; Merkel Cell Carcinoma; Neuroendocrine Differentiation;

D O I：

10.1186/1746-1596-2-35

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Colorectal small cell carcinoma (SmCC) is a rare tumor with an aggressive course. The aim of this study is to summarize our experience with this tumor and to highlight its immunohistochemical profile. Ten cases of colorectal SmCC were identified in our files and a panel of immunostains was performed. Follow up was available for the average of 3 years, during which 7 patients died and 3 were alive with disease. All cases were positive for LMWK, CK 19 and pancytokeratin but were negative for TTF-1 and CA 125. EGFR was positive in 7 cases. TTF-1 negative staining may be valuable in differentiating it from its pulmonary counterpart. CDX2, mCEA, CD56, synaptophysin, NSE and chromogranin can help differentiate it from non-endocrine poorly differentiated adenocarcinoma. The expression of EGFR in a subset of patients has not been reported earlier and has to be evaluated in larger series to assess its role in the planning of targeted biologic therapy.

引用

页数：7

共 36 条

[21] Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma [J].

Lau, SK ;

Prakash, S ;

Geller, SA ;

Alsabeh, R .

HUMAN PATHOLOGY, 2002, 33 (12) :1175-1181

[22]

LEVENSON RM, 1981, J NATL CANCER I, V67, P607

[23] Therapy and outcome of small cell carcinoma of the kidney - Report of two cases and a systematic review of the literature [J].

Majhail, NS ;

Elson, P ;

Bukowski, RM .

CANCER, 2003, 97 (06) :1436-1441

[24]

Medgyesy DC, 2000, CANCER-AM CANCER SOC, V88, P262

[25] SMALL-CELL UNDIFFERENTIATED CARCINOMA OF THE COLON - A CLINICOPATHOLOGICAL STUDY OF 5 CASES AND THEIR ASSOCIATION WITH COLONIC ADENOMAS [J].

MILLS, SE ;

ALLEN, MS ;

COHEN, AR .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1983, 7 (07) :643-651

[26] Long-term survivors after the resection of limited esophageal small cell carcinoma [J].

Mitani, M ;

Kuwabara, Y ;

Shinoda, N ;

Sato, A ;

Fujii, Y .

DISEASES OF THE ESOPHAGUS, 2000, 13 (03) :259-261

[27] Small cell carcinoma of the esophagus; clinicopathological and immunohistochemical analysis of six cases [J].

Noguchi, T ;

Takeno, S ;

Kato, T ;

Wada, S ;

Noguchi, T ;

Uchida, Y ;

Kashima, K ;

Yokoyama, S .

DISEASES OF THE ESOPHAGUS, 2003, 16 (03) :252-258

[28] Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas [J].

Ordóñez, NG .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2000, 24 (09) :1217-1223

[29] EXTRAPULMONARY AND PULMONARY SMALL-CELL CARCINOMA - TUMOR BIOLOGY, THERAPY, AND OUTCOME [J].

REMICK, SC ;

RUCKDESCHEL, JC .

MEDICAL AND PEDIATRIC ONCOLOGY, 1992, 20 (02) :89-99

[30] EXTRAPULMONARY SMALL-CELL CARCINOMA - A REVIEW OF THE LITERATURE WITH EMPHASIS ON THERAPY AND OUTCOME [J].

REMICK, SC ;

HAFEZ, GR ;

CARBONE, PP .

MEDICINE, 1987, 66 (06) :457-471

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