Highly effective synthesis of 4-halo-tetrahydropyrans via a highly diastereoselective in situ prins-type cyclization reaction

被引:102
作者
Yang, J [1 ]
Viswanathan, GS [1 ]
Li, CJ [1 ]
机构
[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA
关键词
D O I
10.1016/S0040-4039(99)00027-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction of aldehyde with homoallyl alcohols mediated by indium trichloride generated 4-chlorotetrahydropyrans in high yields and,vith high stereoselectivity. The same type of compounds can be generated through a single step, multi-component coupling between aldehyde and allyl bromide mediated by indium (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:1627 / 1630
页数:4
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