Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent

被引：20

作者：

Jeong, LS ^{[1
]}

Lee, YA

Moon, HR

Chun, MW

机构：

[1] Ewha Womans Univ, Coll Pharm, Med Chem Lab, Seoul 120750, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 08期

关键词：

D O I：

10.1080/07328319808003481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel apio dideoxynucleosides with azido or amino substituent synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4-conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HIV-1, HSV-1,2 and poliovirus nor toxic.

引用

页码：1473 / 1487

页数：15

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