Systems biology of transcription control in macrophages

被引：23

作者：

Ravasi, Timothy

Wells, Christine A.

Hume, David A. ^{[1
]}

机构：

[1] Univ Edinburgh, Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[2] Univ Calif San Diego, Jacobs Sch Engn, Dept Bioengn, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Scripps NeuroAIDS Preclin Studies Ctr, La Jolla, CA 92093 USA

[4] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia

来源：

BIOESSAYS | 2007年 / 29卷 / 12期

关键词：

D O I：

10.1002/bies.20683

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study of the mammalian immune system offers many advantages to systems biologists. The cellular components of the mammalian immune system are experimentally tractable; they can be isolated or differentiated from in vivo and ex vivo sources and have an essential role in health and disease. For these reasons, the major effectors cells of the innate immune system, macrophages, have been a particular focus in international genome and transcriptome consortia. Genome-scale analysis of the transcriptome, and transcription initiation has enabled the construction of predictive models of transcription control in macrophages that identify the points of control (the major nodes of networks) and the ways in which they interact.

引用

页码：1215 / 1226

页数：12

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