Enantioselective borohydride 1,4-reduction of α,β-unsaturated carboxamides using optically active cobalt(II) complex catalysts

被引：51

作者：

Yamada, T ^{[1
]}

Ohtsuka, Y ^{[1
]}

Ikeno, T ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 11期

关键词：

D O I：

10.1246/cl.1998.1129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective borohydride reduction catalyzed by cobalt(II) complex was successfully applied to 1,4-reduction of beta,beta-disubstituted alpha,beta-unsaturated carboxamides. In the presence of less than 1 mol% of optically active aldiminato cobalt(II) complex catalyst, the corresponding carboxamides were obtained in high yields with high enantiomeric excesses.

引用

页码：1129 / 1130

页数：2

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