Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice

被引：145

作者：

Gutknecht, Lise ^{[1
]}

Waider, Jonas ^{[1
]}

Kraft, Stefanie ^{[1
]}

Kriegebaum, Claudia ^{[1
]}

Holtmann, Bettina ^{[2
]}

Reif, Andreas ^{[1
]}

Schmitt, Angelika ^{[1
]}

Lesch, Klaus-Peter ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, D-97080 Wurzburg, Germany

[2] Univ Wurzburg, DFG Res Ctr Expt Biomed, Rudolf Virchow Ctr, D-97078 Wurzburg, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 08期

关键词：

tryptophan hydroxylase 2; Tph2; knockout; serotonin; development; depression; attention-deficit/hyperactivity disorder;

D O I：

10.1007/s00702-008-0096-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The relative contribution of the two tryptophan hydroxylase (TPH) isoforms, TPH1 and TPH2, to brain serotonergic system function is controversial. To investigate the respective role of TPH2 in neuron serotonin (5-HT) synthesis and the role of 5-HT in brain development, mice with a targeted disruption of Tph2 were generated. The preliminary results indicate that in Tph2 knockout mice raphe neurons are completely devoid of 5-HT, whereas no obvious alteration in morphology and fiber distribution are observed. The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation.

引用

页码：1127 / 1132

页数：6

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