Dual Responsiveness of a Tunable Thermosensitive Polypeptide

被引：58

作者：

Chopko, Caroline M. ^{[1
]}

Lowden, Erika L. ^{[1
]}

Engler, Amanda C. ^{[1
]}

Griffith, Linda G. ^{[2
,3
]}

Hammond, Paula T. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Mech Engn, Dept Biol Engn, Cambridge, MA 02139 USA

[3] MIT, Ctr Gynepathol Res, Cambridge, MA 02139 USA

来源：

ACS MACRO LETTERS | 2012年 / 1卷 / 06期

基金：

美国国家科学基金会;

关键词：

2-(2-METHOXYETHOXY)ETHYL METHACRYLATE; POLYMERS; POLYMERIZATION;

D O I：

10.1021/mz300088w

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The temperature- and pH-dependent solubility of poly(gamma-propargyl L-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a broad range of conditions by varying the ratio of substitution of short oligo(ethylene glycol) and diisopropylamine side groups.

引用

收藏

页码：727 / 731

页数：5

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