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Low levels of ventricular CSF orexin/hypocretin in advanced PD

被引：144
作者：
Drouot, X
Moutereau, S
Nguyen, JP
Lefaucheur, JP
Créange, A
Remy, P
Goldenberg, F
d'Ortho, MP
机构：
[1] Univ Paris 12, INSERM, U421, Serv Physiol Explorat Fonct, F-94010 Creteil, France
[2] Hop Henri Mondor, Assistance Publ Hop Paris, Fac Med Creteil, F-94010 Creteil, France
[3] Hop Henri Mondor, Assistance Publ Hop Paris, Serv Biochim, F-94010 Creteil, France
[4] Hop Henri Mondor, Assistance Publ Hop Paris, Serv Neurochirurg, F-94010 Creteil, France
[5] Hop Henri Mondor, Assistance Publ Hop Paris, Serv Neurol, F-94010 Creteil, France
来源：
NEUROLOGY | 2003年 / 61卷 / 04期
关键词：
D O I：
10.1212/01.WNL.0000078194.53210.48
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.
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页码：540 / 543
页数：5
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