Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

被引：1709

作者：

Zhang, Jian ^{[1
,2
]}

Li, Sha ^{[1
,2
]}

Li, Lu ^{[3
]}

Li, Meng ^{[1
]}

Guo, Chongye ^{[1
]}

Yao, Jun ^{[4
]}

Mi, Shuangli ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Shandong Univ, Jinan Cent Hosp, Dept Obstet & Gynecol, Shandong 250013, Peoples R China

[4] Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China

来源：

GENOMICS PROTEOMICS & BIOINFORMATICS | 2015年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

RETICULOCYTES IN-VITRO; TRANSFERRIN RECEPTOR; SELECTIVE EXTERNALIZATION; MULTIVESICULAR BODIES; MESSENGER-RNAS; CANCER-CELLS; PLASMA; EXPRESSION; MECHANISM; MICROVESICLES;

D O I：

10.1016/j.gpb.2015.02.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Exosomes are 40-100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal miRNAs, since the miRNA profiles of exosomes may differ from those of the parent cells. Exosomal miRNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal miRNAs, and briefly describe how exosomes and their miRNAs function in recipient cells. Finally, we will discuss the potential applications of these miRNA-containing vesicles in clinical settings.

引用

收藏

页码：17 / 24

页数：8

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